Detailed Explanation:

Both Kushanas and Cheras established extensive trade relations with the Roman Empire during the early centuries CE. The Kushanas, ruling from Gandhara and northwestern India, facilitated overland trade via the Silk Route, while their ports on the western coast enabled maritime commerce.

The Cheras of southern India traded actively through ports like Musiri and Tondi, exporting spices, pearls, and textiles to Rome. Archaeological evidence includes Roman coins found in both Kushana and Chera territories, confirming these commercial links.

Therefore, more than one dynasty established trade relations with Rome, making Option 5 the correct answer.